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But a strong pour-over or a dark espresso-based drink can push well past 300 mg in the same volume

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Physicians must have systems in place for tracking patients over time monitoring for adverse effects, assessing muscle mass changes, evaluating dietary habits, and managing the rebound weight gain that frequently occurs when patients stop the drug

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21 An exhaustive review of randomized controlled trials of antidepressant treatment of panic disorder concluded that antidepressants may be more effective than placebo, but the evidence was not strong enough to firmly recommend their use in clinical practice