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PMID: 9849822 Reported Bone-growth effects (preclinical) Longitudinal bone-growth rate increase without IGF-1 elevation (15-day rat study) Johansen and colleagues (Growth Horm IGF Res 1999) reported that adult female rats dosed with ipamorelin for 15 days showed a dose-dependent increase in longitudinal bone-growth rate (from 42 m/day in controls to 4452 m/day) with concurrent body-weight gain
higher doses prolong detection
Clinical concern regarding skeletal muscle changes during GLP-1RA therapy remains debated [40], and preclinical studies have reported context-dependent protection against muscle wasting in selected settings [42, 43]
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