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in Cell Metabolism note that SIRT1 activation improves mitochondrial efficiency and promotes a shift toward lipid utilization for energy, which can be especially beneficial in endurance and fat-loss settings (Price et al., Cell Metabolism )

[1] [4] For weight management, Zepbound is indicated for adults with a BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity

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MOTS-c is encoded in the mitochondrial genome itself, which is why it is studied as part of a distinct signalling class mitochondrial-derived peptides rather than alongside conventional nuclear-encoded peptides