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neither carries a regulatory determination of efficacy or safety for human therapeutic use

While there are no universally agreed-upon "optimal" ranges, practitioners and specialty lab testing companies may base these on the levels of micronutrients in the blood that are associated with the best health outcomes (not just the absence of disease) in clinical research studies

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This can be particularly appealing to patients who have struggled with low levels in the past and want something more reliable than oral supplements

Hyperhomocysteinemia (HHcy), affecting approximately 85% of CKD patients, is a risk factor associated with renal function decline [156]