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Inhibiting this enzyme is examined in the literature for its effect on intracellular NAD availability , which is why 5-Amino-1MQ is frequently used as a research tool in NAD pathway and cellular energy-metabolism studies rather than as a substitute for NAD itself
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5-Amino-1MQ operates as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme central to regulating nicotinamide metabolism and intracellular NAD+ levels
5 ResearchGate (2021)Combined NNMT inhibition and reduced-calorie diet normalizes body composition in obese mice
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