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TB-500 binds monomeric G-actin through the central LKKTETQ motif, sequestering actin monomers and modulating the cytoplasmic pool available for filament elongation in cell-based assays
2, 2000, pp
Because wound healing depends heavily on cells migrating into the injured area endothelial cells forming vessels, fibroblasts laying down matrix, keratinocytes closing the surface a molecule that promotes cell migration is mechanistically interesting for recovery
The overexpression of A20 was also shown to reduce lipogenesis and adipogenesis via lowering levels of sterol regulatory element binding protein-1c (SREBP-1c) and aP2, causing lower fat accumulation in differentiated 3T3-L1 cells [83]
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