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Di Cairano ES, Davalli AM, Perego L, et al
Other proteins [lysozyme, LF (and peptide derivatives of itlactoferricin and lactoferrampin), -lactalbumin, transferring, and osteopontin (OPN)] within human milk are recognized as important AMPs functioning via various mechanisms some of which enhance the anti-inflammatory effects of human milk (59, 64, 67)
Although melanin itself provides protection against reactive oxygen species (ROS) and toxic free radicals, paradoxically, the biosynthesis of melanin itself generates ROS that may cause DNA damage
Secondly, significant weight loss and the resultant change in the inflammatory phenotype of obese adipose tissue would reduce the release into the circulation of key pro-fibrotic pro-inflammatory cytokines/adipokines such as TNF-, IL-6, leptin [31], visfatin and resistin, and increase levels of anti-fibrotic adipokines such as adiponectin [32]
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