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1 Janssen Research & Development, LLC, Raritan, NJ, USA, 2 Center of Excellence in Diabetes and Endocrinology, Sacramento, CA, USA
Single-cell differential gene expression analysis between hepatocytes from semaglutide-versus vehicle-treated animals revealed a strong upregulation of genes involved in amino acid biosynthesis and metabolism, a trend shared across nearly all hepatic cell types ( Figure 6D-E )
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14 Factors like genetics, starting weight, adherence to medication and lifestyle changes, and the presence of other health conditions all play a role