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Related to this, Rodriguez-Perez and colleagues (110, 129) used intrastriatal 6-OHDA injections to produce dopaminergic degeneration and noted a significant decrease in DA neurons in ovariectomized rats
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Nrf2 regulates a variety of antioxidant enzymes and proteins to exert antioxidant effects and inhibit ferroptosis, including Superoxide Dismutases (SODs), HO-1, NAD(P)H-associated enzymes, GPX4, catalase (CAT), FPN, TFR, TF, System Xc-, ferrochelatase (FECH), etc
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