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Certain medicines, such as valproate
In type 2 diabetes, the reduced expression of HO-1 will increase the production of ROS, leading to oxidative stress and inflammatory reaction, further aggravating cell damage (Table 2)
No claims are made regarding biological activity in humans or animals
While the exact mechanisms through which GLP-1 RAs contribute to weight loss are still under investigation, it is believed that they interact with the central and peripheral nervous systems, reducing appetite and food intake
In a study that compared the effects of SCS and placebo for 6 months in 60 patients with DPN refractory to medical therapy, the VAS score decreased significantly only in the SCS group (Table 2) [101]
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