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To identify DPP-IV inhibitory compounds, the leaves of various plant orders, including Myrtales, Fabales, Sapindales, Gentianales, Urticales, Ericales, and Liliales, have been studied ( Figure 3 )for example, the leaves of different plants from the order Myrtales, such as Psidium guajava (29), Eucalyptus globulus , Eucalyptus citriodora , and Eucalyptus camaldulensis (30), have IC 50 values against DPP-IV activity of 380, 3.098, 6.138, and 3.99 g ml -1 , respectively
S2B, C)
In parallel, triple agonists simultaneously targeting GIP, GLP-1, and GCG receptors are also under investigation, aiming to deliver greater WL and metabolic improvements than mono- or dual-agonists
Epitalon is mechanistically robust, translationally immature, but positioned as a serious contender in future longevity protocols
Frontiers in Human Neuroscience, 7
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