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FOXO4-DRI is a large peptide (~5382 Da, 48 amino acids) with a critical structural modification: the D-Retro-Inverso (DRI) design uses D-amino acids in reversed sequence to confer protease resistance while maintaining the 3D spatial arrangement needed for target binding

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IR is characterized by a poor response to insulin whereby glucose uptake is impaired regardless of insulin levels (Boucher et al., 2014)

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