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In particular, a reduced folate intake would be an important determinant of carotid stenosis related to hyperhomocysteinemia (Selhub et al, 1995), and a decrease in plasma folate concentration below 13.6 nmol/L would be associated with a gradual increase in the risk of coronary artery disease (Morrison et al, 1996

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Factors that influence permeability include the gut microbiome and fatty acids (whether ingested directly or as products of bacterial fermentation) (151)

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