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p53 tumour-suppressor caution Because FOXO4-DRI intervenes in the p53 pathway, which is critical for tumour suppression, there is theoretical concern that interfering with p53 dynamics might carry oncogenic risk
The ratio of Firmicutes to Bacteroidetes is a commonly-studied change with an increase often linked to HFD consumption/obesity in mice 43,44 and humans 45,46 (for review, see John and Mullin, 2016 47 )
It appears to stimulate the expression of growth factors and support the structural repair of axons and myelin sheaths, highlighting its potential as a therapeutic agent for various forms of neuropathy and nerve damage
*Correspondence: Chih-Yuan Ko, [email protected] ORCID: Qiao-Wen Chen, orcid.org/0009-0008-5135-2627
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