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43 The superiority of oral semaglutide in reducing HbA1c was observed as early as at week 26
These alterations change the hypothalamic neuropeptide expression: the expression of CA-AMPK enhances the effect of fasting, increasing the expression of NPY and AgRP in the ARC and the melanin-concentrating hormone in the lateral hypothalamus, whereas the hypothalamic expression of DN-AMPK decreases the expression of orexigenic neuropeptides NPY and AgRP in ARC [88, 118]
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