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In STEP-1 (N=1,961), semaglutide 2.4 mg produced 14.9% mean body weight loss at 68 weeks versus 2.4% with placebo, and the lipid improvements tracked closely with this weight reduction 1

Patients should eat smaller, more frequent meals rather than large portions, avoiding high-fat and heavily spiced foods that may exacerbate nausea

Use Telehealth for Support Accessing timely medical advice is crucial when managing side effects

A total of 577 patients were randomly assigned (1:1:1) to receive once-weekly dulaglutide (1.5 mg), once-weekly dulaglutide (0.75 mg), or daily insulin glargine as basal therapy, all in combination with insulin lispro, for 52 weeks

Topiramate, originally approved for seizure management and migraine prevention, reduces appetite by modulating GABA receptors and carbonic anhydrase activity