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Specific concerns include post-cholecystectomy syndrome (a cluster of persistent GI symptoms in 1015% of patients) and potential interactions between GLP-1-induced motility changes and pre-existing bile acid malabsorption
Wegovy (semaglutide) It was the first weekly injectable GLP-1 approved specifically for weight management in adults with a body mass index of 30 or higher, or 27 and above with at least one weight-related condition such as high blood pressure or type 2 diabetes
Nanoplatforms contribute to obesity therapy by enhancing drug delivery, extending pharmacokinetic half-life, and maintaining continuous GLP-1R stimulation, which is essential for sustained weight loss [235]
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