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Vermeulen, L
in the 1980s, MT-2 peptide features a lactam bridge that confers enhanced metabolic stability compared to the native -MSH sequence
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In melanoma patients refractory to antiPD-1 therapy, the combination of Talimogene laherparepvec (T-VEC), an oncolytic herpesvirus, with pembrolizumab (NCT04068181) showed enhanced systemic immune activation and tumor response
This is clearly demonstrated in people living with DS, where the overexpression of CBS is a genetic consequence that causes a significant reduction of serum homocysteine concentration leading to less available methionine within the methionine cycle
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