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Quality of life improvements Multiple quality-of-life domains showed significant improvement
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Treatment involves gradual dose titration, regular monitoring of HbA1c, weight, renal function, and assessment for adverse effects such as gastrointestinal symptoms or pancreatitis
Quick answer In the REDEFINE trials CagriSema is given once weekly by subcutaneous injection, with both components titrated in parallel from 0.25 mg + 0.25 mg up to a 2.4 mg + 2.4 mg weekly target
However, this approach raises concerns about the higher risk of side effects due to more frequent dosing, challenges in patient adherence due to daily injections, and the potential for an overstimulated immune response
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