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The phase 2 type 2 diabetes trial evaluated maintenance doses including 0.5 mg, 4 mg, 8 mg, and 12 mg, with several escalation designs [5]

23 : 18831883 Pisano C, Camerini B, Castorina M, Olivi A, Ambrosini A, Calvani M

The rebound effect upon GLP-1R agonists withdrawal needs to be investigated further, and new drug developments should aim to mitigate this big limitation and find ways in which GLP-1R agonists could be used as short-term therapies without causing weight regain and cardiometabolic risk reversal

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Verma S, Petrie MC, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Shah SJ, Ronnback C, Abildstrom SZ, Liisberg K, et al