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Water retention plateaus typically resolve within 5 to 7 days and often follow identifiable triggers like high sodium meals, hormonal changes, or new exercise routines

Most patients experience some degree of nausea initially, but with appropriate dose titration, dietary modifications, and sometimes supportive medications, the majority find side effects tolerable and worth enduring for the appetite control and weight loss benefits they experience

Alternatively, extensive unrepaired DNA damage can trigger the apoptotic pathway

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Osbourne stopped taking the drug after she hit less than 100 pounds, saying, "The heaviest I was 230 pounds and I'm now under 100