However, mood symptoms may return if weight is regained, if previous coping patterns reemerge, or if individuals find that weight loss alone does not resolve underlying issues related to relationships, self-esteem, or other psychosocial concerns
1 A 2025 trial published in the New England Journal of Medicine, which directly compared the two medications, found that tirzepatide produced greater weight loss than semaglutide 2.4 mg
Here are three must-dos: Always consult healthcare professionals
Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials (Sattar et al.)
The two can also be used simultaneously at different doses