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Owens C W I, Belcher R V
It has a favorable topical tolerability signal in cosmetics and preclinical models, but there is no published human trial quantifying its side effects, and no systemic/injectable safety data at all
(PubMed) Traber MG
J Appl Bacteriol (1983) 54:41723
Multiple in vitro studies have demonstrated that NAC actively induces the non-immunological degranulation of mast cells, causing them to dump pre-formed histamine directly into the bloodstream, which can trigger immediate allergic-type symptoms
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