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S., Ugel, S., Tsirigos, A., Bronte, V., Munn, D

Relationship between disrupted intestinal barrier and disease incidence Three basic elements are interdependent: altered microbiota, disrupted intestinal barrier, disease

Differences in cancer outcome definitions across trials were addressed by grouping clinically equivalent endpoints (e.g., hepatocellular carcinoma and primary liver cancer) and accounting for heterogeneity through random-effects modeling, sensitivity analyses, and GRADE downgrading for indirectness where appropriate

Daily subcutaneous administration is the standard research protocol