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In diet-induced obese (DIO) mouse models, 5-Amino-1MQ treatment produced significant reductions in body weight, white adipose tissue mass, and adipocyte cell size without significant effects on food intake suggesting a metabolic rather than appetite-suppressing mechanism

Strategic timing of carbohydrate intake around training while maintaining lower carbohydrates at other times may enhance fat oxidation during peptide administration windows

References Sourced from Neelakantan et al., Biochemical Pharmacology (2018), on NNMT inhibitors reversing diet-induced obesity in mice