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Using gene-edited mice with humanised GLP-1 receptors, the team found that oral small-molecule GLP-1 drugs activated the central amygdala, a region associated with desire and reward that sits deeper in the brain than the hypothalamic and hindbrain networks where injectable peptide GLP-1s have been shown to act
Goodman was interested in a hormone called somatostatin, which is produced in the brain and the pancreas
FOXO transcription factors differ in their dynamics and intra/intermolecular interactions
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