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Gallbladder-related events, including cholelithiasis (gallstones) and cholecystitis, were reported in a small number of participants receiving active treatment a finding consistent with the known class effect of GLP-1 receptor agonists

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Preliminary findings indicate that GLP-1 harbors a key sequence that directly binds to and inhibits the activation of TRPV1 channels in sensory neurons

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Metabolic Adaptation and Ketone Production As the body begins to burn stored fat, mild ketosis can develop