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The company has, however, postponed US regulatory filing for the drug due to manufacturing constraints

These concerns are not theoretical

In consideration of the dual roles of GLP-1RAs in hypoglycemic effects and preventing CVD among T2DM patients, we reviewed the cardiovascular effects and molecular mechanisms of GLP-1RAs in CVOTs, animal models and cultured cells, and discuss how these findings transform pharmacotherapies for T2DM, and even expand the indication of this important category of anti-diabetic drugs to CVD patients without diabetes

Woodworth JC, Minton JE, Tokach MD, Nelssen JL, Goodband RD, Dritz SS, et al

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