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Nature (2020) 585(7823):1138

Both assays confirm the ATPase stimulating effect of heme while showing that the tested reductants do not show typical effects of ABC transporter substrates

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Accordingly, mitochondrial dysfunction can lead to early signs of neurodegeneration or synaptic deficits, as well as distinct cognitive deficits without A deposits being present, a new situation recently called Suspected non-amyloid pathology (SNAP)