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The body will break down B12 if it has no use for it, and since it is water-soluble the excess will be eliminated naturally

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Risk rises when factors accumulate, for example dose escalation, timing near large meals, existing reflux, or diabetic neuropathy, and a small subset of users, about 1 in 50 (2%), report persistent hiccups that need clinical attention

The exact half-life in humans is not fully confirmed, detection windows remain uncertain, and long-term safety data is still lacking

This systematic review and dose-response network meta-analysis addresses this gap, analyzing gastrointestinal adverse events from GLP-1 RAs in non-diabetic subjects with overweight or obesity