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pro-BNP, N-terminal pro-Brain natriuretic peptide

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This review highlights the changes of certain gut microbes in patients with atherosclerosis, hypertension, heart failure, myocardial infarction, atrial fibrillation (AF), and chronic kidney disease (CKD), respectively ( Supplementary Table 1 )

The trials produced signals consistent with the mechanism (the peptide does what its pharmacology predicts it would do), but the effect sizes were not large enough to support a successful path to drug approval as a standalone obesity treatment