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Dang JT, Vaughan T, Mocanu V et al (2023) Conversion of sleeve gastrectomy to Roux-en-Y gastric bypass: indications, prevalence, and safety
This reflects direct glucagon receptordriven lipid mobilization and hepatic fat utilization
As MOTS-c activates AMPK and NRF2, it also indirectly suppresses the mTOR (mechanistic target of rapamycin) pathway, the master growth and anabolism regulator that, when chronically overactivated, accelerates the accumulation of senescent cells
2 These were typically mild to moderate and most common when the dose increased
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