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Inhibition of SGLT2 reduces sodium reabsorption in the proximal tubule and enhances Na + delivery to the macula densa, promoting finally the TGF activation with consequent afferent arteriole vasoconstriction and reduction of the single-nephron-glomerular-filtration-rate ( Figure 1 )
The consistency should not be watery nor too thick - more glitter or mix may be added as needed
In the STEP trials (semaglutide) and SURMOUNT trials (tirzepatide) for obesity, participants with baseline binge eating behaviors showed improvements in eating-related measures alongside weight loss, as assessed by questionnaires such as the Control of Eating Questionnaire
Key Takeaway: To successfully use your HSA/FSA for GLP-1s, ensure you have a valid prescription, keep all your itemized receipts, and request a Letter of Medical Necessity from your provider to keep on file
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