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12,399 These tools have revolutionized our ability to dissect the biological features of malignant tumor cells, uncover intratumoral heterogeneity and its dynamic evolution, elucidate tumor-immune cell interactions, and uncover mechanisms of drug resistance and relapse, paving the way for personalized treatment strategies to improve patient outcomes (Fig

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The specific upstream triggers of each disease (such as A, ischemia and hemorrhage) activate these common downstream pathological processes, which in turn are the direct upstream activators of the core ferroptosis machinery (iron overload, lipid peroxidation and antioxidant system depletion)

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