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Artificial intelligence for multimodal data integration in oncology
In line with late endosomal cholesterol accumulation interfering with Rab7 activity in cell-based models [12, 17, 18], U18666A treatment of brain-like organoids from wildtype hESC resulted in a ~ 25% reduction of Rab7-GTP levels and caused a significant cholesterol accumulation (Fig
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In addition, ASTX improved intracellular redox status by preventing the increase in hepatic reactive oxygen species (ROS) levels and by promoting a significant increase in the activity of the antioxidant enzymes catalase (CAT) and glutathione S-transferase (GST)
Neutrophil-derived proteolytic enzymes (i.e., myeloperoxidase and elastase) may also be involved in the initiation of AT inflammation (132)
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