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These benefits are possibly attributed to the modulation of enteric neuronal function and tight junction expression by exendin-4, as evidenced by reduced occludin levels [56]
Longer-term continuous use (6+ months) has less established safety data, though no significant concerns have emerged
For instance, VK has been showed to suppress TLR2/TLR4-mediated NF-B activation, attenuating hippocampal hyperexcitability while preserving Gas6/Axl/Akt pro-survival signaling,which is a dual mechanism mitigating both neuroinflammation and OS-induced neuronal apoptosis [12]
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