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p62 activators Two compounds able to increase p62 levels, trehalose and rapamycin, have been demonstrated to increase nuclear translocation of NRF2 in a p62-dependent manner and to enhance expression of its downstream antioxidant factors, HO1 and NQO1, in a hepatoma cellular system [308] and in a preclinical model of FRDA [309]

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Its plausible, they wrote, that new blood vessels could accelerate cancer by carrying extra oxygen to tumors

However, since factors other than glutathione contribute to acrolein resistance, the ALE strategy often yielded strains with reduced glutathione content (Nho et al., 2025)