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In the STEP-4 (Effect and Safety of Semaglutide 2.4 mg Once-Weekly in Subjects With Overweight or Obesity Who Have Reached Target Dose During Run-in Period) trial, 16 participants who discontinued semaglutide after 20 weeks regained a mean 6.9% of their baseline body weight over 48 weeks
According to FDA labeling for Wegovy (semaglutide 2.4 mg), patients should be evaluated after 12 weeks at the maintenance dose, and discontinuation considered if less than 5% weight loss has been achieved
(29423816) indications, advantages [1] Suspected/known acetaminophen intoxication (discussed above)
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