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Providers must carefully manage concurrent pharmacotherapy that also raises blood glucose (for example, loop and thiazide diuretics), which can reduce GLP-1 RA efficacy
The high molecular mass of GLP-1s suggests that transfer across the placenta wouldnt be expected, but given the lack of knowledge, women using them for weight loss (who do not have diabetes) are advised to stop before trying to conceive
Love how the Patient Page breaks down the MEAL planespecially the cue to start each plate with 2030 g of protein to protect muscle while GLP1s blunt appetite In my practice with clients, anchoring meals with that protein bump keeps postmeal glucose steadier, and pairing it with slowdigesting carbs plus a drizzle of olive oil sticks better
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Hepatic glucose production, hepatic lipid content, and broader hepatic biology research have documented retatrutide effects beyond what GLP-1-only or dual-agonist compounds deliver
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