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cloned the cDNA of human HGF and clarified the primary structure of HGF, and identified HGF as a novel growth factor that has a unique structural characteristic (Miyazawa et al., 1989
Additional ongoing studies target JAK/STAT signaling with SHR-0302 and SHR-2554 (NCT06519526), as well as agents modulating the Notch (e.g., MK-0752, NCT00106145), Hippo (e.g., IK-930, NCT05228015), and GAS6/AXL (e.g., bemcentinib, NCT02424617) pathways in a variety of advanced or resistant tumors
Monitoring for signs of dehydrationincluding decreased urine output, dry mouth, and dizzinessis essential, particularly during dose escalation periods when gastrointestinal side effects are most pronounced
doi: 10.1186/2191-219X-3-31 123 VavereALKridelSJWheelerFBLewisJS
Depending on dose, 64100% of retatrutide-treated individuals achieved at least 5% weight loss (a common benchmark for clinical success) versus 27% on placebo
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