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The percentage of patients who achieved a clinically meaningful treatment response (defined as achieving at least 5% weight loss after 1 year of treatment) ranged from 36% to 57% with CONTRAVE, compared to 17% to 43% with placebo
Abstract Chronic treatment with GLP-1R agonists may moderately lower blood pressure due to increased natriuresis and RAAS inhibition
The significance of STEP-HFpEF trial is that it demonstrated benefits of semaglutide in nondiabetic patients with HFpEF and obesity
The APCP treatment was a commercial-grade product available in Korea, and this study was conducted to provide evidence of proof of concept
A 2005 study used a dose of2 g per day
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