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Size at birth and cord blood levels of insulin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-1 (IGFBP-1), IGFBP-3, and the soluble IGF-II/mannose-6-phosphate receptor in term human infants
When this ratio collapses, the cell enters a state of severe oxidative stress, leading to accelerated aging, mitochondrial dysfunction, and eventually, cellular death (apoptosis)
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