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Notably, BSA-PA significantly increased tau phosphorylation at residues T181, S262, and S396/S404 (PHF-1) compared to cells treated with BSA alone, without significant changes in total tau levels (Fig 2)
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Downstream effects (IGF-1 elevation, body composition changes, recovery markers) take 24 weeks to manifest because IGF-1 synthesis lags behind GH pulses
Aging, as the bodys ability to absorb and utilize vitamin B12 may decrease with age
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