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Since, IGF-1R has been known to be involved in the pathogenesis of psoriasis and upregulated in psoriasis, they studied the relationship between miR-99a and IGF-1R

FIGURE 3 2.4 GPX4 Glutathione peroxidase 4 (GPX4) is a membrane-associated phospholipid hydroperoxidase and the only enzyme in the GPX family that directly reduces and destroys lipid hydroperoxides, GPX4 is characterized early and characterizes as the lipid peroxidation inhibitory protein PIP, mainly due to its unique ability ( 2 O 2 and small molecule hydroperoxides, it is also capable of reducing complex lipid compounds such as phospholipids, cholesterol and cholesterol lipid hydroperoxides

This variability can cause repeated episodes of nerve ischemia and reperfusion, leading to further oxidative damage and inflammatory responses

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Under physiological conditions, the cytoplasmic protein Kelch-like ECH-associated protein 1 (Keap1), an adapter protein of Cullin-3-based ubiquitin ligase, binds to NRF2 to suppress NRF2 activation by mediating its ubiquitination and degradation (Fig