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Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously: results from a phase 1b/2a randomised controlled study
The throughline was operational refinement: a steroid-sparing topical for eczema, a new branded antipsychotic entry, an enzyme replacement therapy anchored to a surrogate biochemical endpoint, and a long-acting peptide engineered for weekly dosing in children
A weak barrier function makes the skin more susceptible to bacteria, irritants, allergens and environmental factors such as pollution and stress
doi: 10.1186/s11658-022-00350-8 167 GaoCWangBChenQWangMFeiXZhaoN
Consolidating the three doses into one, or running it daily like BPC-157, discards that selectivity
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