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For instance, a 2026 preclinical study published in eBioMedicine found that tirzepatide reduced voluntary alcohol consumption and relapse-like drinking behaviors in rodents, potentially by affecting dopamine signaling tied to reward and motivation

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67 Docherty KF, Jhund PS, Inzucchi SE, Kober L, Kosiborod MN, Martinez FA, et al

Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 are generally not considered candidates for GLP-1 therapy