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While its indirect effects are highly pronounced in the arterial system, its direct vasoconstrictive action operates predominantly on the venous system, making it highly effective at elevating venous return and central venous pressure (Statler et al, 2023)

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On December 22, 2025, the FDA approved oral Wegovy (semaglutide 25mg tablet) the first and only oral GLP-1 medication for chronic weight management