Without carbidopa, so much levodopa would need to be ingested to allow for a small amount to make it into the brain, that the side effects of the levodopa, specifically nausea, would not be tolerated by most people
PMID 11368417
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Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases [PMID: 16635254] Laboratory literature summary: Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein
If diet alone is not able to correct vitamin levels, supplements can also be an option