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In respect to their cardiovascular effects among patients with T2DM, both GLP-1RAs and SGLT2is have been shown to reduce the risk of MACE (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke), with GLP-1RAs reducing the risk of non-fatal stroke to a greater extent [3, 6]
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This therapeutic effect is predicated on the ability of GLP-1RAs to cross the BBB and exert direct physiological effects within the brain [21, 22]
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