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We have previously developed two types of murine models by either intraperitoneal injection of ovalbumin (OVA)/aluminum hydroxide (alum) and intratracheal administration of porcine pancreatic elastase (PPE, ACO-a model) or intratracheal administration of papain (ACO-b model) that reflect the heterogeneity of ACO [22]

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This review study analyzes human GLP-1 trials, including protocols via injection that may be considered low dose or microdosing